U.K. Launches Covid-19 Trial To Test Mix And Match Vaccine Program



The University of Oxford will lead the primary trial exploring whether or not completely different Covid-19 vaccines can be utilized interchangeably, the University’s vaccine group said Thursday, an effort that would make vaccination applications extra versatile and even present higher safety in opposition to the illness.

Key Facts

The research, run by the U.Ok. National Immunisation Schedule Evaluation Consortium, will recruit over 800 individuals over the age of fifty to guage the feasibility of utilizing one vaccine for the primary “prime” shot and completely different one for the second “booster” shot.

At first, the trial will use the Oxford-AstraZeneca and Pfizer-BioNTech vaccines, each already cleared for emergency use within the U.Ok., with others probably being added at a later date. 

Britain’s Deputy Chief Medical Officer, Jonathan Van-Tam, mentioned the trial would provide “greater insight” into using vaccines in opposition to Covid-19, and supply knowledge that would help a “extra versatile immunization programme” in mild of worldwide provide chain points. 

“It is also even possible that by combining vaccines, the immune response could be enhanced giving even higher antibody levels that last longer,” Van-Tam added.

The research may also consider the effectiveness of various vaccine mixtures when the booster shot is given after completely different intervals: one after 4 weeks and one other after 12, which is the U.Ok.’s present method in a bid to offer as many individuals some type of immunity as rapidly as attainable. 

If the outcomes are promising, the U.Ok. authorities said it could contemplate altering its nationwide vaccination technique.

Crucial Quote

Professor Matthew Snape, Oxford’s chief investigator on the trial, said: “This is a tremendously exciting study that will provide information vital to the roll out of vaccines in the U.K. and globally… If we do show that these vaccines can be used interchangeably in the same schedule this will greatly increase the flexibility of vaccine delivery, and could provide clues as to how to increase the breadth of protection against new virus strains.”


Some vaccines work higher if a unique vaccine is used for the booster shot, which is named heterologous boosting. Russia’s Sputnik V vaccine, which early research point out to be 92% efficient at stopping Covid-19, makes use of the precept. It makes use of of a unique modified virus in every shot to hold the immunity-conveying directions into the physique. 

Further Reading

Oxford leads first trial investigating dosing with alternating vaccines (Oxford Vaccine Group)

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