New study reveals tiny extracellular vesicles’ big impact on health

High doses of EVs activate lysosomal and repress membrane trafficking genes in vivo. Credit: Science Advances (2023). DOI: 10.1126/sciadv.adh1168

Extracellular vesicles are small cell bubbles that play a crucial role in how our cells communicate. A study published in Science Advances has unlocked some fascinating insights into these tiny messengers and their potential in health care.

Researchers wanted to understand how cells react to these extracellular vesicles (EVs) produced by different cell types and at varying concentrations.

The world of extracellular vesicle (EV) research is relatively new. Scientists used to think that high concentrations of EVs were necessary for an impact. But this study shows that even a small number of EVs can make a big difference by transmitting important information and instructions between cells and revolutionize how we use EVs for treatments.

“Understanding how EVs communicate between cells gives us a better grasp of how our bodies work at a microscopic level. It’s like learning the secret language cells use to chat,” says first and corresponding author Daniel Hagey, Researcher at the Department of Laboratory Medicine.

“Now we plan to work on better techniques to separate EVs from the other stuff floating around our cells. This will make EV research even more precise,” Daniel Hagey continues.

“We also want to test different types of EVs on various cell types. This could help uncover more profound ways cells communicate, mirroring our body’s complex relationships. In essence, this study unravels the hidden world of EVs and their critical role in cell communication. It could pave the way for exciting advancements in health care and our understanding of how our bodies function.”

More information:
Daniel W. Hagey et al, The cellular response to extracellular vesicles is dependent on their cell source and dose, Science Advances (2023). DOI: 10.1126/sciadv.adh1168

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Karolinska Institutet

New study reveals tiny extracellular vesicles’ big impact on health (2023, September 7)
retrieved 7 September 2023

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